Celiac disease in children pdf

Advanced Search. Skip Nav Destination Article Navigation. Close mobile search navigation Article navigation. Volume , Issue 3. Previous Article Next Article. Article Navigation. Articles September 01 Hogen Esch, MD.

Departments of a Pediatric Gastroenterology and. Address correspondence to C. E-mail: c. This Site. Google Scholar. Victorien M. Wolters, MD, PhD. Susan A. Gerritsen, MD ; Susan A. Gerritsen, MD. Mary von Blomberg, PhD ; B. Mary von Blomberg, PhD. Ingrid M. Celiac diseases CD are induced by gluten and related proteins which are like to cause intestinal damage. The major intervention of CD is avoided of gluten rich diet, which usually results … Expand.

View 2 excerpts, cites background. Celiac Disease CD is a systemic chronic immune-mediated disorder triggered after the ingestion of gluten protein in genetically susceptible individuals [1]. CD is manifested by a variety of … Expand. Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg.

The Indian Journal of Pediatrics. View 1 excerpt, cites background. Objectives: Relationship amongst celiac disease CD and lung diseases has been discussed in the past. Studies have documented that CD is linked with lung diseases. CD has also been described to … Expand. Celiac disease does not influence markers of ovarian reserve in adolescent girls. Archives of Gynecology and Obstetrics.

Rotavirus gastroenteritis as a precipitating factor of celiac crisis in infancy: Case reports and review of literature. Accepted papers are articles in press that have gone through due peer review process and have been accepted for publication by the Editorial Board of the Serbian Archives of Medicine. The remaining authors declare no competing interests.

Peer review information. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Related links. These authors contributed equally: M. Ines Pinto-Sanchez, Jocelyn A. National Center for Biotechnology Information , U. Nat Rev Gastroenterol Hepatol. Ines Pinto-Sanchez , 1, 2 Jocelyn A.

Silvester , 3, 4, 5 Benjamin Lebwohl , 6 Daniel A. Leffler , 3, 5, 7 Robert P. Anderson , 8 Amelie Therrien , 3, 5 Ciaran P. Kelly , 3, 5 and Elena F. Verdu 1, 2. Ines Pinto-Sanchez. Jocelyn A. Daniel A. Robert P.

Ciaran P. Elena F. Author information Article notes Copyright and License information Disclaimer. Verdu, Email: ac. Corresponding author. Accepted Aug 4. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. Abstract Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals.

Subject terms: Coeliac disease, Coeliac disease. Table 1 Selected milestones and gaps in coeliac disease. Open in a separate window. Table 2 Selected milestones and current and future research objectives in pathogenesis and genetics. Used in combination with humanized models, microorganisms could influence key mechanisms in coeliac disease e. Table 3 Selected milestones and current and future research objectives in diagnosis, management, therapeutics and prevention of coeliac disease.

Milestones and gaps in pathogenesis Coeliac disease is triggered by the ingestion of gluten in a subgroup of genetically predisposed individuals 2. Challenges Despite the key milestones achieved, there is limited understanding of pathways of disease tolerance and tissue destruction. Opportunities In contrast to other T cell-mediated organ-specific immune diseases, many of which are genetically linked or associated with coeliac disease, researchers can undertake patient-based so-called proof-of-concept studies with outcomes broadly relevant to understanding and treating other conditions.

Challenges Researchers do not know why disease incidence is increasing, although environmental factors including viral infections during childhood or changes in gut microbiota composition or metabolite production 32 , which have led to an increase in many autoimmune and allergic conditions, have been implicated. Opportunities The uncertainty regarding whether and how to screen for coeliac disease in average-risk and high-risk individuals provides the clinical equipoise necessary to justify a randomized trial.

Milestones and gaps in management Major advances in coeliac disease management to date have been identification of the role of gluten in perpetuating the disease 43 , identification of HLA-DQ2. Challenges Studies 47 , 48 show that patients are not able to maintain a strict gluten-free diet owing to the great difficulty of adherence, but, as we are all aware, no alternatives exist as yet. Opportunities There is increasing interest and support from industry for development programmes in coeliac disease, and the number of potential therapeutic targets and clinical trials has grown exponentially over the past 15 years 53 , Milestones and gaps in funding Research in coeliac disease has long been a case of accomplishing much with little.

Challenges The coeliac disease research and dedicated clinical community is barely at replacement levels. Table 4 Models for innovation and potential application in coeliac disease. Opportunities As with many areas of research today, laboratories and clinical groups working individually will only be able to make incremental gains.

Timeline of major advances and discoveries in coeliac disease. Final comments and reflections Over the past decades, the field of coeliac disease has had many research accomplishments to celebrate. Conclusions Overall, we remain confident that research breakthroughs in the near term have the potential to greatly improve clinical care in coeliac disease and facilitate innovations across autoimmunity.

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